Markman, Janet L. and Rekechenetskiy, Arthur and Holler, Eggehard and Ljubimova, Julia Y. (2013) Nanomedicine therapeutic approaches to overcome cancer drug resistance. ADVANCED DRUG DELIVERY REVIEWS, 65 (13-14). pp. 1866-1879. ISSN 0169-409X, 1872-8294
Full text not available from this repository. (Request a copy)Abstract
Nanomedicine is an emerging form of therapy that focuses on alternative drug delivery and improvement of the treatment efficacy while reducing detrimental side effects to normal tissues. Cancer drug resistance is a complicated process that involves multiple mechanisms. Here we discuss the major forms of drug resistance and the new possibilities that nanomedicines offer to overcome these treatment obstacles. Novel nanomedicines that have a high ability for flexible, fast drug design and production based on tumor genetic profiles can be created making drug selection for personal patient treatment much more intensive and effective. This review aims to demonstrate the advantage of the young medical science field, nanomedicine, for overcoming cancer drug resistance. With the advanced design and alternative mechanisms of drug delivery known for different nanodrugs including liposomes, polymer conjugates, micelles, dendrimers, carbon-based, and metallic nanoparticles, overcoming various forms of multi-drug resistance looks promising and opens new horizons for cancer treatment. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PEGYLATED LIPOSOMAL DOXORUBICIN; CELL LUNG-CANCER; MEDIATED PACLITAXEL RESISTANCE; ACUTE MYELOID-LEUKEMIA; TUMOR STEM-CELLS; P-GLYCOPROTEIN; MULTIDRUG-RESISTANCE; BREAST-CANCER; ACID NANOBIOCONJUGATE; LOADED NANOPARTICLES; Nanobiopolymers; Nanodrug; Drug delivery; Tumor multidrug resistance |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Alumni or Retired > Prof. Dr. Eggehard Holler |
| Depositing User: | Petra Gürster |
| Date Deposited: | 19 Jun 2020 09:26 |
| Last Modified: | 19 Jun 2020 09:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15646 |
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