Kaess, Bernhard M. and Gona, Philimon and Larson, Martin G. and Cheng, Susan and Aragam, Jayashree and Kenchaiah, Satish and Benjamin, Emelia J. and Vasan, Ramachandran S. (2013) Secular trends in echocardiographic left ventricular mass in the community: the Framingham Heart Study. HEART, 99 (22). pp. 1693-1698. ISSN 1355-6037, 1468-201X
Full text not available from this repository. (Request a copy)Abstract
Objective To investigate secular trends in echocardiographically determined left ventricular mass (LVM). Design, setting and participants Longitudinal community-based cohort study in Framingham, Massachussetts. LVM was calculated from routine echocardiography in 4320 participants (52% women) of the Framingham offspring cohort at examination cycles 4 (1987-1991), 5 (1991-1995), 6 (1995-1998) and 8 (2005-2008), totalling 13971 person-observations. Main outcome measures Sex-specific trends in mean LVM (and its components, LV diastolic diameter (LVDD) and LV wall thickness (LVWT)), and LVM indexed to body surface area (BSA). Results In men, age-adjusted LVM modestly increased from examination 4 to 8 (192g to 198g, p-trend=0.0005), whereas, in women it decreased from 147g at examination 4 to 140g at examination 8 (p-trend<0.0001). The trend for increasing LVM in men tracked with an increasing LVDD (p-trend=0.0002), whereas the decline in LVM in women was accompanied by a decrease in LVWT (p-trend<0.0001). Indexing LVM to BSA abolished the increasing trend in men (p-trend=0.49), whereas, the decreasing trend in women was maintained. Conclusions In our longitudinal analysis of a large community-based sample spanning two decades, we observed sex-related differences in trends in LVM, with a modest increase of LVM in men (likely attributable to increasing body size), but a decrease in women. Additional studies are warranted to elucidate the basis for these sex-related differences.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENDER-DIFFERENCES; RISK-FACTORS; HYPERTROPHY; HYPERTENSION; INDIVIDUALS; PREVALENCE; REGRESSION; REDUCTION; COMMITTEE; THERAPY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Mar 2020 10:16 |
| Last Modified: | 26 Mar 2020 10:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15673 |
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