Niller, Hans Helmut and Banati, Ferenc and Nagy, Katalin and Buzas, Krisztina and Minarovits, Janos (2013) Update on microbe-induced-epigenetic changes: bacterial-effectors and viral oncoproteins as epigenetic dysregulators. FUTURE VIROLOGY, 8 (11). pp. 1111-1126. ISSN 1746-0794, 1746-0808
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Pathoepigenetics is a new discipline describing how disturbances in epigenetic regulation alter the epigenotype and gene-expression pattern of human, animal or plant cells. Such epigenetic reprogramming' may play an important role in the initiation and progression of a wide variety of diseases. Infectious diseases also belong to this category: recent data demonstrated that microbial pathogens, including bacteria and viruses, are capable of dysregulating the epigenetic machinery of their host cell. The resulting heritable changes in host cell gene expression may favor the colonization, growth or spread of infectious pathogens. It may also facilitate the establishment of latency and malignant cell transformation. In this article, we review how bacterial epigenetic effectors and inflammatory processes elicited by bacteria alter the host cell epigenotype, and describe how oncoproteins encoded by human tumor viruses act as epigenetic dysregulators to alter the phenotype and behavior of host cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPSTEIN-BARR-VIRUS; TUBERCULOSIS 19-KDA LIPOPROTEIN; HELICOBACTER-PYLORI INFECTION; PAPILLOMAVIRUS E7 ONCOPROTEIN; GASTRIC EPITHELIAL-CELLS; HISTONE CHAPERONE SPT6; DNA METHYLATION; GENE-EXPRESSION; PLASMODIUM-FALCIPARUM; NUCLEAR ANTIGEN; DNA methylation; epigenetic regulation; histone modification; oncovirus; pathoepigenetics; pioneer transcription factor; Polycomb and Trithorax complexes; tumorigenesis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 19 Jun 2020 09:21 |
| Last Modified: | 19 Jun 2020 09:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15689 |
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