Camboni, Daniele and Rojas, Alvaro and Sassalos, Peter and Spurlock, David and Koch, Kelly L. and Menchak, Sarah and Singleton, Jennifer and Boothman, Erika and Haft, Jonathan W. and Bartlett, Robert H. and Cook, Keith E. (2013) Long-Term Animal Model of Venovenous Extracorporeal Membrane Oxygenation with Atrial Septal Defect as a Bridge to Lung Transplantation. ASAIO JOURNAL, 59 (6). pp. 558-563. ISSN 1058-2916, 1538-943X
Full text not available from this repository. (Request a copy)Abstract
This study evaluated the effectiveness of an atrial septal defect (ASD) with venovenous extracorporeal membrane oxygenation (vv-ECMO) as a bridge to transplantation. Sheep (56 +/- 3 kg; n = 7) underwent a right-sided thoracotomy to create the ASD (diameter = 1 cm) and place instrumentation and a pulmonary artery (PA) occluder. After recovery, animals were placed on ECMO, and the PA was constricted to generate a twofold rise in right ventricular (RV) systolic pressure. Sheep were then maintained for 60 hours on ECMO, and data were collected hourly. Five sheep survived 60 hours. One sheep died because of a circuit clot extending into the RV, and another died presumably because of an arrhythmia. Mean right ventricular pressure (mRVP) was 19 +/- 3 mm Hg at baseline, averaged 27 +/- 7 mm Hg over the experiment, but was not statistically significant (p = 0.27) due to one sheep without an increase. Cardiac output was 6.8 +/- 1.2 L/min at baseline, averaged 6.0 +/- 1.0 L/min during the experiment, and was statistically unchanged (p = 0.34). Average arterial oxygen saturation and PCO2 over the experiment were 96.8 +/- 1.4% and 31.8 +/- 3.4 mm Hg, respectively. In conclusion, an ASD combined with vv-ECMO maintains normal systemic hemodynamics and arterial blood gases during a long-term increase in RV afterload.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRIMARY PULMONARY-HYPERTENSION; RIGHT-VENTRICULAR FAILURE; SEPTOSTOMY; right ventricular failure; pulmonary failure; ECLS; lung transplant; septostomy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2020 09:56 |
| Last Modified: | 25 Mar 2020 09:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15746 |
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