Arzt, Michael and Schroll, Stephan and Series, Frederic and Lewis, Keir and Benjamin, Amit and Escourrou, Pierre and Luigart, Ruth and Kehl, Victoria and Pfeifer, Michael (2013) Auto-servoventilation in heart failure with sleep apnoea: a randomised controlled trial. EUROPEAN RESPIRATORY JOURNAL, 42 (5). pp. 1244-1254. ISSN 0903-1936, 1399-3003
Full text not available from this repository. (Request a copy)Abstract
We tested the hypotheses that in patients with congestive heart failure (CUP) and sleep disordered breathing (SDB) auto-servoventilation (ASV) improves cardiac function and quality of life. Between March 2007 and September 2009, patients with stable CHF (left ventricular ejection fraction (LVEF) <= 40%) and SDB (apnoea/hypopnoea index >= 20 events.h(-1)) were randomised to receive either ASV (BiPAP ASV (Philips Respironics, Murrysville, PA, USA), n=37) and optimal medical management, or optimal medical management alone (n=35). Outcomes were assessed at baseline and 12 weeks. The apnoea/hypopnoea index assessed with polysomnography scored in one core laboratory was significantly more reduced in the ASV group (-39 +/- 16 versus -1 +/- 13 events.h(-1); p<0.001) with an average use of 4.5 +/- 3.0 h.day(-1). Both groups showed similar improvements of the primary end-point LVEF (+3.4 +/- 5 versus + 3.5 +/- 6%; p=0.915) assessed with echocardiography. In the ASV group, reduction of N-terminal probrain natriuretic peptide (NT-proBNP) was significantly greater (-360 +/- 569 versus +135 +/- 625 ng.mL(-1); p=0.010). No differences were observed between the groups in subjective quality of life. In patients with CHF and SDB, ASV reduced NT-proBNP levels, but improvement of LVEF or quality of life was not greater than in the control group. The data support that such patients can be randomised in large-scale, long-term trials of positive airway pressure therapy versus control to determine effects on cardiovascular outcome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSITIVE AIRWAY PRESSURE; CHEYNE-STOKES RESPIRATION; NATRIURETIC PEPTIDE; VENTRICULAR DYSFUNCTION; EUROPEAN-SOCIETY; BLOOD-PRESSURE; ASSOCIATION; VENTILATION; PREDICTORS; GUIDELINES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2020 10:03 |
| Last Modified: | 25 Mar 2020 10:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15748 |
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