Altomonte, Jennifer and Marozin, Sabrina and De Toni, Enrico N. and Rizzani, Antonia and Esposito, Irene and Steiger, Katja and Feuchtinger, Annette and Hellerbrand, Claus and Schmid, Roland M. and Ebert, Oliver (2013) Antifibrotic Properties of Transarterial Oncolytic VSV Therapy for Hepatocellular Carcinoma in Rats With Thioacetamide-Induced Liver Fibrosis. MOLECULAR THERAPY, 21 (11). pp. 2032-2042. ISSN 1525-0016, 1525-0024
Full text not available from this repository. (Request a copy)Abstract
Recombinant vesicular stomatitis virus (VSV) shows promise for the treatment of hepatocellular carcinoma (HCC), but its safety and efficacy when administered in a setting of hepatic fibrosis, which occurs in the majority of clinical cases, is unknown. We hypothesized that VSV could provide a novel benefit to the underlying fibrosis, due to its ability to replicate and cause cell death specifically in activated hepatic stellate cells. In addition to the ability of VSV to produce a significant oncolytic response in HCC-bearing rats in the background of thioacetamide-induced hepatic fibrosis without signs of hepatotoxicity, we observed a significant downgrading of fibrosis stage, a decrease in collagen content in the liver, and modulation of gene expression in favor of fibrotic regression. Together, this work suggests that VSV is not only safe and effective for the treatment of HCC with underlying fibrosis, but it could potentially be developed for clinical application as a novel antifibrotic agent.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VESICULAR STOMATITIS-VIRUS; HEPATIC STELLATE CELLS; APOPTOSIS; CIRRHOSIS; REVERSAL; EPIDEMIOLOGY; INHIBITION; ACTIVATION; EXPRESSION; DIAGNOSIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2020 10:12 |
| Last Modified: | 25 Mar 2020 10:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15749 |
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