Treutlein, Jens and Frank, Josef and Streit, Fabian and Reinbold, Celine S. and Juraeva, Dilafruz and Degenhardt, Franziska and Rietschel, Liz and Witt, Stephanie H. and Forstner, Andreas J. and Ridinger, Monika and Strohmaier, Jana and Wodarz, Norbert and Dukal, Helene and Foo, Jerome C. and Hoffmann, Per and Herms, Stefan and Heilmann-Heimbach, Stefanie and Soyka, Michael and Maier, Wolfgang and Gaebel, Wolfgang and Dahmen, Norbert and Scherbaum, Norbert and Mueller-Myhsok, Bertram and Lucae, Susanne and Ising, Marcus and Stickel, Felix and Berg, Thomas and Roggenbuck, Ulla and Joeckel, Karl-Heinz and Scholz, Henrike and Zimmermann, Ulrich S. and Buch, Stephan and Sommer, Wolfgang H. and Spanagel, Rainer and Brors, Benedikt and Cichon, Sven and Mann, Karl and Kiefer, Falk and Hampe, Jochen and Rosendahl, Jonas and Noethen, Markus M. and Rietschel, Marcella (2017) Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. GENES, 8 (7): 183. ISSN 2073-4425,
Full text not available from this repository. (Request a copy)Abstract
The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus in a gene-based approach (p(uncorrected) = 1.2 x 10(-6); p(corrected) = 0.020). This was driven by the AD subsample. No association with ADH1B was found in the combined ACP + ALC sample. On first inspection, this seems surprising, since ADH1B is a robustly replicated risk gene for AD and may therefore be expected to be associated also with subgroups of AD patients. The negative finding in the ACP + ALC sample, however, may reflect genetic stratification as well as random fluctuation of allele frequencies in the cases and controls, demonstrating the importance of large samples in which the phenotype is well assessed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; ALDEHYDE DEHYDROGENASE; EUROPEAN-AMERICANS; MAXIMUM NUMBER; LIVER-DISEASE; ADH1C GENE; RISK LOCI; POLYMORPHISMS; METAANALYSIS; METABOLISM; alcohol dependence; chronic alcoholic pancreatitis; alcoholic liver cirrhosis; genome-wide association study; alcohol dehydrogenase; ADH1B; ADH1C |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 28 Feb 2019 11:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1575 |
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