Heinlin, Julia and Zimmermann, Julia L. and Zeman, Florian and Bunk, Wolfram and Isbary, Georg and Landthaler, Michael and Maisch, Tim and Monetti, Roberto and Morfill, Gregor and Shimizu, Tetsuji and Steinbauer, Julia and Stolz, Wilhelm and Karrer, Sigrid (2013) Randomized placebo-controlled human pilot study of cold atmospheric argon plasma on skin graft donor sites. WOUND REPAIR AND REGENERATION, 21 (6). pp. 800-807. ISSN 1067-1927, 1524-475X
Full text not available from this repository. (Request a copy)Abstract
Cold atmospheric plasma has already been shown to decrease the bacterial load in chronic wounds. However, until now it is not yet known if plasma treatment can also improve wound healing. We aimed to assess the impact of cold atmospheric argon plasma on the process of donor site healing. Forty patients with skin graft donor sites on the upper leg were enrolled in our study. The wound sites were divided into two equally sized areas that were randomly assigned to receive either plasma treatment or placebo (argon gas) for 2 minutes. Donor site healing was evaluated independently by two blinded dermatologists, who compared the wound areas with regard to reepithelialization, blood crusts, fibrin layers, and wound surroundings. From the second treatment day onwards, donor site wound areas treated with plasma (n=34) showed significantly improved healing compared with placebo-treated areas (day 1, p=0.25; day 2, p=0.011; day 3, p<0.001; day 4, p<0.001; day 5, p=0.004; day 6, p=0.008; day 7, p=0.031). Positive effects were observed in terms of improved reepithelialization and fewer fibrin layers and blood crusts, whereas wound surroundings were always normal, independent of the type of treatment. Wound infection did not occur in any of the patients, and no relevant side effects were observed. Both types of treatment were well tolerated. The mechanisms contributing to these clinically observed effects should be further investigated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONTHERMAL PLASMA; CONTROLLED-TRIAL; CHRONIC WOUNDS; NITRIC-OXIDE; MEDICINE; CELLS; DERMATOLOGY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Mar 2020 11:58 |
| Last Modified: | 26 Mar 2020 11:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15765 |
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