Thomson, Emma and Ferreira-Cerca, Sebastien and Hurt, Ed (2013) Eukaryotic ribosome biogenesis at a glance. JOURNAL OF CELL SCIENCE, 126 (21). pp. 4815-4821. ISSN 0021-9533, 1477-9137
Full text not available from this repository. (Request a copy)Abstract
Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic cells, ribosome biogenesis requires the coordinated activity of all three RNA polymerases and the orchestrated work of many (>200) transiently associated ribosome assembly factors. The biogenesis of ribosomes is a tightly regulated activity and it is inextricably linked to other fundamental cellular processes, including growth and cell division. Furthermore, recent studies have demonstrated that defects in ribosome biogenesis are associated with several hereditary diseases. In this Cell Science at a Glance article and the accompanying poster, we summarise the current knowledge on eukaryotic ribosome biogenesis, with an emphasis on the yeast model system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SMALL NUCLEOLAR RNAS; POLYMERASE-I TRANSCRIPTION; NUCLEAR EXPORT; SACCHAROMYCES-CEREVISIAE; PRE-RIBOSOMES; CYTOPLASMIC MATURATION; PRERIBOSOMAL RNA; 60S SUBUNITS; TRANSLATION INITIATION; PROCESSING FACTORS; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Apr 2020 09:01 |
| Last Modified: | 01 Apr 2020 09:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15769 |
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