Grube, Matthias and Loeffler, Juergen and Mezger, Markus and Krueger, Bernd and Echtenacher, Bernd and Hoffmann, Petra and Edinger, Matthias and Einsele, Hermann and Andreesen, Reinhard and Holler, Ernst (2013) TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. MEDICAL MYCOLOGY, 51 (8). pp. 818-825. ISSN 1369-3786, 1460-2709
Full text not available from this repository. (Request a copy)Abstract
Single nucleotide polymorphisms (SNPs) have been associated with an increased incidence of invasive aspergillosis (IA) after allogeneic stem cell transplantation (allo-SCT). We analyzed 41 patients with proven/probable IA after allo-SCT for an association of SNPs, within the TLR2, TLR4, TLR5, TLR9, and NOD2/CARD15 genes, with susceptibility to IA. The control group consisted of 130 patients who had allo-SCT but did not develop IA. While no association was found for donor SNPs and the recipients' risk of IA, analysis of recipient SNPs showed a significant association between the presence of recipient TLR5-Stop SNP (1174C>T) and the incidence of IA (P = 0.004). Multivariate analysis demonstrated that the recipient TLR5-Stop SNP appeared as an independent risk factor for IA after allo-SCT. Our study suggests that TLR5 is involved in host defense against Aspergillus fumigatus, and that the recipient TLR5-Stop SNP represents a risk factor for the development of IA after allo-SCT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TOLL-LIKE RECEPTORS; NOD2/CARD15 VARIANTS; BACTERIAL FLAGELLIN; FUNGAL-INFECTIONS; FUMIGATUS CONIDIA; SUSCEPTIBILITY; ACTIVATION; EXPRESSION; RECOGNITION; MECHANISMS; TLR; polymorphism; aspergillosis; stem cell transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Apr 2020 10:46 |
| Last Modified: | 01 Apr 2020 10:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15773 |
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