Kretz, Markus (2013) TINCR, staufen1, and cellular differentiation. RNA BIOLOGY, 10 (10). pp. 1597-1601. ISSN 1547-6286, 1555-8584
Full text not available from this repository. (Request a copy)Abstract
The human genome encodes several thousand long non-protein coding transcripts > 200 nucleotides in length, a subset of which were shown to play important roles in regulation of gene expression. We recently identified TINCR, a lncRNA required for induction of key differentiation genes in epidermal tissue, including genes mutated in human skin diseases characterized by disrupted epidermal barrier formation. High-throughput analyses of TINCR RNA- and protein-interactomes revealed TINCR interaction with differentiation mRNAs as well as the Staufen1 protein. TINCR, together with Staufen1, seems to stabilize a subset of mRNAs required for epidermal differentiation. Here, we discuss the emerging roles of Staufen1 and TINCR in the regulation of mammalian cell differentiation mediated by interaction with target mRNAs. We consider a role for TINCR as an epithelial-specific guide for targeting the Staufen1 protein to specific mRNAs, reflecting the increasing complexity of gene regulatory processes in mammalian cells and tissue.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LONG NONCODING RNA; EMBRYONIC STEM-CELLS; ANTISENSE RNA; GENE; DECAY; EXPRESSION; CHROMATIN; CANCER; MOUSE; TRANSLATION; lncRNA; TINCR; STAU1; epidermis; skin; non-coding RNA; differentiation |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 05:42 |
| Last Modified: | 30 Mar 2020 05:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15882 |
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