Husser, Oliver and Monmeneu, Jose V. and Bonanad, Clara and Gomez, Cristina and Chaustre, Fabian and Nunez, Julio and Lopez-Lereu, Maria P. and Minana, Gema and Sanchis, Juan and Mainar, Luis and Ruiz, Vicente and Forteza, Maria J. and Trapero, Isabel and Moratal, David and Chorro, Francisco J. and Bodi, Vicente (2013) Head-to-head comparison of 1 week versus 6 months CMR-derived infarct size for prediction of late events after STEMI. INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 29 (7). pp. 1499-1509. ISSN 1569-5794, 1573-0743
Full text not available from this repository. (Request a copy)Abstract
Infarct size (IS) at 1 week after ST-elevation myocardial infarction (MI) diminishes during the first months. The incremental prognostic value of IS regression and of scar size (SS) at 6 months is unknown. We compared cardiovascular magnetic resonance (CMR)-derived IS at 1 week and SS at 6 months after MI for predicting late major adverse cardiac events (MACE). 250 patients underwent CMR at 1 week and 6 months after MI. IS and SS were determined as the extent of transmural late enhancement (in > 50 % of wall thickness, ETLE). During 163 weeks, 23 late MACE (cardiac death, MI or readmission for heart failure after the 6 months CMR) occurred. Patients with MACE had a larger IS at 1 week (6 [4-9] vs. 3 [1-5], p < .0001) and a larger SS at 6 months (5 [2-6] vs. 3 [1-5], p = .005) than those without MACE. Late MACE rates in IS > median were higher at 1 week (14 vs. 4 %, p = .007) and in SS > median at 6 months (12 vs. 5 %, p = .053). The C-statistic for predicting late MACE of CMR at 1 week and 6 months was comparable (.720 vs. .746, p = .1). Only ETLE at 1 week (HR 1.31 95 % CI [1.14-1.52], p < .0001, per segment) independently predicted late MACE. CMR-derived SS at 6 months does not offer prognostic value beyond IS at 1 week after MI. The strongest predictor of late MACE is ETLE at 1 week.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE MYOCARDIAL-INFARCTION; CARDIOVASCULAR MAGNETIC-RESONANCE; MICROVASCULAR OBSTRUCTION; PROGNOSTIC VALUE; HYPERTROPHY; REPERFUSION; DYSFUNCTION; RECOVERY; FAILURE; Cardiovascular magnetic resonance; ST-elevation myocardial infarction; Prognosis; Late gadolinium enhancement imaging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 07:32 |
| Last Modified: | 30 Mar 2020 07:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15935 |
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