Maurovich-Horvat, Eszter and Kemlink, David and Hoegl, Birgit and Frauscher, Birgit and Ehrmann, Laura and Geisler, Peter and Ettenhuber, Katharina and Mayer, Geert and Peraita-Adrados, Rosa and Calvo, Elena and Lammers, Gert Jan and Van der Heide, Astrid and Ferini-Strambi, Luigi and Plazzi, Giuseppe and Poli, Francesca and Dauvilliers, Yves and Jennum, Poul and Leonthin, Helle and Mathis, Johannes and Wierzbicka, Aleksandra and Puertas, Francisco J. and Beitinger, Pierre A. and Arnulf, Isabelle and Riha, Renata L. and Tormasiova, Maria and Slonkova, Jana and Nevsimalova, Sona and Sonka, Karel (2013) Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies. JOURNAL OF SLEEP RESEARCH, 22 (5). pp. 496-512. ISSN 0962-1105, 1365-2869
Full text not available from this repository. (Request a copy)Abstract
In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n=216) and without cataplexy (n=33) completed a self-administrated questionnaire regarding pregnancy and childbirth. The cohort was divided further into patients whose symptoms of narcolepsy started before or during pregnancy (308 pregnancies) and those in whom the first symptoms of narcolepsy appeared after delivery (106 pregnancies). Patients with narcolepsy during pregnancy were older during their first pregnancy (P<0.001) and had a higher body mass index (BMI) prior to pregnancy (P<0.01). Weight gain during pregnancy was higher in narcoleptic patients with cataplexy (P<0.01). More patients with narcolepsy-cataplexy during pregnancy had impaired glucose metabolism and anaemia. Three patients experienced cataplexy during delivery. The rate of caesarean sections was higher in the narcolepsy-cataplexy group compared to the narcolepsy group (P<0.05). The mean birth weight and gestational age of neonates were within the normal range and did not differ across groups. Neonatal care was affected adversely by symptoms of narcolepsy in 60.1% of those with narcolepsy during pregnancy. This study reports more obstetric complications in patients with narcolepsy-cataplexy during pregnancy; however, these were not severe. This group also had a higher BMI and higher incidence of impaired glucose metabolism during pregnancy. Caesarian section was conducted more frequently in narcolepsy-cataplexy patients, despite cataplexy being a rare event during delivery. Furthermore, symptoms of narcolepsy may render care of the infant more difficult.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MULTIPLE-SCLEROSIS; WOMEN; CATAPLEXY; OUTCOMES; cataplexy; delivery; metabolism; newborn; pregnancy; puerperium |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 09:25 |
| Last Modified: | 30 Mar 2020 09:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15949 |
Actions (login required)
 |
View Item |
