Siegloch, Kristina and Schmitz, Norbert and Wu, Huei-Shan and Friedrichs, Birte and van Imhoff, Gustaaf W. and Montoto, Silvia and Holler, Ernst and Maria Ribera, Josep and Delage, Robert and Duehrsen, Ulrich and del Castillo, Nerea and Harrison, Beth and Dreger, Peter and Sureda, Anna (2013) Hematopoietic Stem Cell Transplantation in Patients with Lymphomatoid Granulomatosis: A European Group for Blood and Marrow Transplantation Report. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 19 (10). pp. 1522-1525. ISSN 1083-8791, 1523-6536
Full text not available from this repository. (Request a copy)Abstract
Lymphomatoid granulomatosis (LG) is a very rare, Epstein-Barr virus-associated lymphoproliferative disorder of B cells. Prognosis is poor, particularly after relapse and no curative treatment exists. We report the results of high-dose therapy and autologous stem cell transplantation (ASCT) or reduced-intensity conditioning and allogeneic stem cell transplantation (alloSCT) in patients with multiply relapsed LG. A European Group for Blood and Marrow Transplantation survey identified 10 patients who had received 9 ASCT and 4 alloSCT. All patients had active disease at the time of transplantation. With a median follow-up of 5.1 (range, 1.4 to 6.3) years, 6 patients are alive and disease-free. Two ASCT patients died of septicemia early after transplantation, and 1 committed suicide after being in continuous complete remission 19 months after ASCT. Another patient allografted 4 years after ASCT remained disease-free but died of severe graft-versus-host disease 3 months after alloSCT. High-dose therapy followed by ASCT and alloSCT are effective therapeutic options and should be considered in all patients with refractory and multiply relapsed LG. (C) 2013 American Society for Blood and Marrow Transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Stem cell transplantation; Lymphomatoid granulomatosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 11:08 |
| Last Modified: | 30 Mar 2020 11:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15956 |
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