Gungor, Baris and Ekmekci, Ahmet and Arman, Ahmet and Ozcan, Kazim S. and Ucer, Ekrem and Alper, Ahmet T. and Calik, Nazmi and Yilmaz, Hale and Tezel, Tuna and Coker, Ajda and Bolca, Osman (2013) Assessment of Interleukin-1 Gene Cluster Polymorphisms in Lone Atrial Fibrillation: New Insight into the Role of Inflammation in Atrial Fibrillation. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 36 (10). pp. 1220-1227. ISSN 0147-8389, 1540-8159
Full text not available from this repository. (Request a copy)Abstract
BackgroundSystemic inflammation is accepted as one of the pathophysiological mechanisms of atrial fibrillation (AF). The role of inflammation has been shown previously. Interleukin (IL) system is the main modulator of the inflammatory responses and genetic polymorphisms of IL-1 cluster genes are associated with increased risk for inflammatory diseases. ObjectivesTo investigate the association between polymorphisms of IL-1 cluster genes and lone AF. Subjects and MethodsDNA samples were collected from 70 proven lone AF patients and 70 healthy subjects. Genomic DNA was typed for the variable number of the tandem repeat (VNTR) IL-1 receptor antagonist (RN) gene polymorphism, IL-1B -511 C > T(rs16944) promoter polymorphism, and +3953 C > T(rs1143634) polymorphism in exon 5 by polymerase chain reaction. ResultsIn lone AF group the frequency of IL-1RN2/2 and IL-1RN1/2 genotypes were higher than in the control group (7.2% vs 4.3% and 48.5% vs 22.8%, respectively; (2) = 14.1; P = 0.028). The frequency of allele 2 was significantly higher in the lone AF group (32.1% vs 15.7%; (2) = 10.7; P = 0.005). Allele and genotype distribution of IL-1B -511 C > T and +3953 C > T polymorphisms were not statistically different between the groups. C-reactive protein (CRP) levels were higher in lone AF patients compared to the control group (median = 1.25, interquartile range [IQR] = 0.85 vs median = 1.08, IQR 0.46 mg/L, respectively; P = 0.02). In multivariate regression analysis, presence of allele 2 of IL-1 VNTR polymorphism and elevated plasma high-sensitive-CRP levels were the independent predictors of lone AF. ConclusionPresence of allele 2 of VNTR polymorphism of IL-1RN gene may cause increased risk for lone AF probably due to the inadequate limitation of inflammatory reactions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; OF-FUNCTION MUTATION; RECEPTOR ANTAGONIST; RHEUMATOID-ARTHRITIS; MYOCARDIAL-INFARCTION; ISCHEMIC-STROKE; IN-VITRO; RISK; ANAKINRA; lone atrial fibrillation; interleukin polymorphism; CRP |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 11:43 |
| Last Modified: | 30 Mar 2020 11:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15970 |
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