May, Matthias and Aziz, Atiqullah and Zigeuner, Richard and Chromecki, Thomas and Cindolo, Luca and Schips, Luigi and De Cobelli, Ottavio and Rocco, Bernardo and De Nunzio, Cosimo and Tubaro, Andrea and Coman, Ioman and Truss, Michael and Dalpiaz, Orietta and Hoschke, Bernd and Gilfrich, Christian and Feciche, Bogdan and Stoltze, Anette and Fenske, Fabian and Fritsche, Hans-Martin and Figenshau, Robert S. and Madison, Kerry and Sanchez-Chapado, Manuel and Santiago Martin, Maria del Carmen and Salzano, Luigi and Lotrecchiano, Giuseppe and Joniau, Steven and Waidelich, Raphaela and Stief, Christian and Brookman-May, Sabine (2013) Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma: an analysis of the multicenter CORONA database. WORLD JOURNAL OF UROLOGY, 31 (5). pp. 1073-1080. ISSN 0724-4983, 1433-8726
Full text not available from this repository. (Request a copy)Abstract
To investigate gender differences in clinicopathological features and to analyze the prognostic impact of gender in renal cell carcinoma (RCC) patients undergoing surgery. A total of 6,234 patients (eleven centers; Europe and USA) treated by radical or partial nephrectomy were included in this retrospective study (median follow-up 59 months; IQR 30-106). Gender differences in clinicopathological parameters were assessed. Multivariable Cox regression models were applied to determine the influence of parameters on disease-specific survival (DSS) and overall survival (OS). A total of 3,751 patients of the study group were male patients (60.2 %), who were significantly younger at diagnosis and received more frequently NSS than women. Significantly, more often high-grade tumors and simultaneous metastasis were present in men. Whereas tumor size and pTN stages did not differ between genders, clear-cell and chromophobe RCC was diagnosed less frequently, but papillary RCC more often in men. Gender also independently influenced DSS (HR 0.75, p < 0.001) and OS (HR 0.80, p < 0.001) with a benefit for women. However, inclusion of gender in multivariable models did not significantly gain predictive accuracies (PA) for DSS (0.868-0.870, p = 0.628) and OS (0.775-0.777, p = 0.522). Furthermore, no significantly different DSS and OS rates were found in patients undergoing NSS. This study demonstrates important gender differences in clinicopathological features and outcome of RCC patients with improved DSS and OS for women compared to men, even if solely patients with clear-cell RCC or M0-stage are taken into evaluation. However, inclusion of gender in multivariable models does not significantly gain PA of multivariable models.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMORS; MODELS; Renal cell carcinoma; Gender; Age groups; Nephrectomy; Histological subtypes; Prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 12:39 |
| Last Modified: | 30 Mar 2020 12:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15975 |
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