Walter, B. and Weiss, T. and Hofstaedter, F. and Gaumann, A. and Hartmann, A. and Rogenhofer, S. and Ganzer, R. and Wach, S. and Engehausen, D. and Wieland, W. F. and Blana, A. (2013) Utility of immunohistochemistry markers in the interpretation of post-high-intensive focussed ultrasound prostate biopsy cores. WORLD JOURNAL OF UROLOGY, 31 (5). pp. 1129-1133. ISSN 0724-4983,
Full text not available from this repository. (Request a copy)Abstract
To overcome the difficulties in the interpretation of postoperative tumor obtaining biopsy cores for patients who treated their prostate cancer with high-intensity focussed ultrasound (HIFU) therapy. The H&E slides of 58 patients with residual prostate cancer after HIFU treatment were systematically reviewed. Correlation between the pathologist's findings and immunohistochemical expression of MIB-1, alpha-Methyl-Co-Racemase and 34 beta E-12 staining was analyzed. Mean time from treatment to biopsy was 40.2 (8-208) weeks. The expert review of the H&E slides identified 40 patients with viable carcinoma in the post-HIFU biopsy cores. 18 patients were revised to necrosis-only-tumors. These biopsies were performed not later than 16 weeks after HIFU treatment (median 10.9 weeks, range 8-14). Both MIB-1 and AMACR staining displayed significant differential expression in viable carcinoma (p < 0.001) compared to necrosis tumors. Referring to viable carcinoma tissue, AMACR staining index was significantly rising, the longer treatment dated back from biopsy (p < 0.002). In this context, 34-beta-E12 stained negative through all tumor areas and positive in the majority (85%) of the surrounding non-neoplastic epithelium. AMACR and MIB-1 reliably differentiate viable carcinoma from a process of ongoing irreversible necrosis in early post-HIFU prostate biopsy cores and therefore proposed-in addition with 34 beta-E12-as useful markers exposing suspicious tumor foci in difficult cases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIFU TREATMENT; CANCER; ADENOCARCINOMA; CARCINOMA; RACEMASE; THERAPY; Prostate cancer; High-intensity focused ultrasound; Post-HIFU treatment biopsy; Immunohistochemistry |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 12:41 |
| Last Modified: | 30 Mar 2020 12:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15976 |
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