Di Benedetto, Barbara and Rupprecht, Rainer and Czeh, Boldizsar (2013) Talking to the Synapse: How Antidepressants Can Target Glial Cells to Reshape Brain Circuits. CURRENT DRUG TARGETS, 14 (11). pp. 1329-1335. ISSN 1389-4501, 1873-5592
Full text not available from this repository. (Request a copy)Abstract
Functional alterations in synaptic contacts in specific brain areas are a hallmark of major depressive disorder (MDD). Antidepressant treatments not only readjust the aberrant concentrations of neurotransmitters in the synaptic clefts, but have the capacity to reshape neuronal circuits by affecting synaptogenesis and synaptic stabilization in specific regions of the brain. Nevertheless, the underlying molecular mechanisms are still unclear. Glial cells are active partners of neurons in orchestrating molecular signals that regulate the arrangement of neuronal circuits both in the developing and adult brain. Here, we present evidences indicating that glial cells might be substrates of antidepressant action for restructuring neuronal networks that has become miswired after the onset or progression of MDD. We aim to offer an alternative approach (a "gliocentric" view) to study this complex neuropsychiatric disorder and to identify alternative mechanisms of action for the currently available antidepressant therapies. Such knowledge may help to improve current treatment regimens or identify novel targets for the development of more efficacious antidepressant drugs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAJOR DEPRESSIVE DISORDER; EXCITATORY SYNAPSES; CNS SYNAPTOGENESIS; DENDRITIC SPINES; MOOD DISORDERS; TNF-ALPHA; MICROGLIA; ASTROCYTES; PLASTICITY; HIPPOCAMPUS; Astrocyte; major depressive disorder; microglia; mood disorder; synaptic plasticity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 12:48 |
| Last Modified: | 30 Mar 2020 12:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15981 |
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