Kliese, N. and Gobrecht, P. and Pachow, D. and Andrae, N. and Wilisch-Neumann, A. and Kirches, E. and Riek-Burchardt, M. and Angenstein, F. and Reifenberger, G. and Riemenschneider, M. J. and Meese, E. and Panayotova-Dimitrova, D. and Gutmann, D. H. and Mawrin, C. (2013) miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells. ONCOGENE, 32 (39). pp. 4712-4720. ISSN 0950-9232,
Full text not available from this repository. (Request a copy)Abstract
Meningiomas are frequent, mostly benign intracranial or spinal tumors. A small subset of meningiomas is characterized by histological features of atypia or anaplasia that are associated with more aggressive biological behavior resulting in increased morbidity and mortality. Infiltration into the adjacent brain tissue is a major factor linked to higher recurrence rates. The molecular mechanisms of progression, including brain invasion are still poorly understood. We have studied the role of micro-RNA 145 (miR-145) in meningiomas and detected significantly reduced miR-145 expression in atypical and anaplastic tumors as compared with benign meningiomas. Overexpression of miR-145 in IOMM-Lee meningioma cells resulted in reduced proliferation, increased sensitivity to apoptosis, reduced anchorage-independent growth and reduction of orthotopic tumor growth in nude mice as compared with control cells. Moreover, meningioma cells with high miR-145 levels had impaired migratory and invasive potential in vitro and in vivo. PCR-array studies of miR145-overexpressing cells suggested that collagen type V alpha (COL5A1) expression is downregulated by miR-145 overexpression. Accordingly, COL5A1 expression was significantly upregulated in atypical and anaplastic meningiomas. Collectively, our data indicate an important anti-migratory and anti-proliferative function of miR-145 in meningiomas.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INSULIN-RECEPTOR SUBSTRATE-1; EHLERS-DANLOS-SYNDROME; PROSTATE-CANCER; EXPRESSION; GENE; INVASIVENESS; GROWTH; BRAIN; LINE; ESTABLISHMENT; miRNA; meningioma; invasion; collagen type 5 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Neuropathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Mar 2020 11:50 |
| Last Modified: | 31 Mar 2020 11:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16013 |
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