Klein, Christoph A. (2013) Selection and adaptation during metastatic cancer progression. NATURE, 501 (7467). pp. 365-372. ISSN 0028-0836, 1476-4687
Full text not available from this repository. (Request a copy)Abstract
Cancer is often regarded as a process of asexual evolution driven by genomic and genetic instability. Mutation, selection and adaptation are by convention thought to occur primarily within, and to a lesser degree outside, the primary tumour. However, disseminated cancer cells that remain after 'curative' surgery exhibit extreme genomic heterogeneity before the manifestation of metastasis. This heterogeneity is later reduced by selected clonal expansion, suggesting that the disseminated cells had yet to acquire key traits of fully malignant cells. Abrogation of the cells' progression outside the primary tumour implies new challenges and opportunities for diagnosis and adjuvant therapies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISSEMINATED TUMOR-CELLS; PRIMARY COLORECTAL CANCERS; BREAST-CANCER; BONE-MARROW; CLONAL EVOLUTION; IN-SITU; ADHESION MOLECULE; GENOMIC ANALYSIS; GENETIC-ANALYSIS; DIVERSITY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für experimentelle Medizin und Therapieverfahren |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Mar 2020 12:10 |
| Last Modified: | 31 Mar 2020 12:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16022 |
Actions (login required)
 |
View Item |
