Al Ghazal, Philipp and Herberger, Katharina and Schaller, Joerg and Stroelin, Anke and Hoff, Norman-Philipp and Goerge, Tobias and Roth, Hannelore and Rabe, Eberhard and Karrer, Sigrid and Renner, Regina and Maschke, Jan and Horn, Thomas and Hepp, Julia and Eming, Sabine and Wollina, Uwe and Zutt, Markus and Sick, Isabell and Splieth, Benno and Dill, Dorothea and Klode, Joachim and Dissemond, Joachim (2013) Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients. ORPHANET JOURNAL OF RARE DISEASES, 8: 136. ISSN 1750-1172,
Full text not available from this repository. (Request a copy)Abstract
Background: Pyoderma gangrenosum (PG) is a rarely diagnosed ulcerative neutrophilic dermatosis with unknown origin that has been poorly characterized in clinical studies so far. Consequently there have been significant discussions about its associated factors and comorbidities. The aim of our multicenter study was to analyze current data from patients in dermatologic wound care centers in Germany in order to describe associated factors and comorbidities in patients with PG. Methods: Retrospective clinical investigation of patients with PG from dermatologic wound care centers in Germany. Results: We received data from 259 patients with PG from 20 different dermatologic wound care centers in Germany. Of these 142 (54.8%) patients were female, 117 (45.2%) were male; with an age range of 21 to 95 years, and a mean of 58 years. In our patient population we found 45.6% with anemia, 44.8% with endocrine diseases, 12.4% with internal malignancies, 9.3% with chronic inflammatory bowel diseases and 4.3% with elevated creatinine levels. Moreover 25.5% of all patients had a diabetes mellitus with some aspects of potential association with the metabolic syndrome. Conclusions: Our study describes one of the world's largest populations with PG. Beside the well-known association with chronic bowel diseases and neoplasms, a potentially relevant new aspect is an association with endocrine diseases, in particular the metabolic syndrome, thyroid dysfunctions and renal disorders. Our findings represent clinically relevant new aspects. This may help to describe the patients' characteristics and help to understand the underlying pathophysiology in these often misdiagnosed patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PAPA SYNDROME; CLINICOPATHOLOGICAL CORRELATION; AUTOINFLAMMATORY SYNDROME; INFLAMMATORY DISEASES; PYOGENIC ARTHRITIS; ACNE; SKIN; TRAFFICKING; MUTATION; Pyoderma gangrenosum; Chronic ulcer; Comorbidities; Metabolic syndrome; Diabetes mellitus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Mar 2020 13:07 |
| Last Modified: | 31 Mar 2020 13:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16043 |
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