Bandulik, S. (2017) Of channels and pumps: different ways to boost the aldosterone? ACTA PHYSIOLOGICA, 220 (3). pp. 332-360. ISSN 1748-1708, 1748-1716
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The mineralocorticoid aldosterone is a major factor controlling the salt and water balance and thereby also the arterial blood pressure. Accordingly, primary aldosteronism (PA) characterized by an inappropriately high aldosterone secretion is the most common form of secondary hypertension. The physiological stimulation of aldosterone synthesis in adrenocortical glomerulosa cells by angiotensin II and an increased plasma K+ concentration depends on a membrane depolarization and an increase in the cytosolic Ca2+ activity. Recurrent gain-of-function mutations of ion channels and transporters have been identified in a majority of cases of aldosterone-producing adenomas and in familial forms of PA. In this review, the physiological role of these genes in the regulation of aldosterone synthesis and the altered function of the mutant proteins as well are described. The specific changes of the membrane potential and the cellular ion homoeostasis in adrenal cells expressing the different mutants are compared, and their impact on autonomous aldosterone production and proliferation is discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADRENAL GLOMERULOSA CELLS; MEMBRANE CALCIUM-PUMP; PROTEIN-KINASE-C; NA+-H+ EXCHANGE; P-TYPE ATPASES; ANGIOTENSIN-II; ZONA GLOMERULOSA; BETA-CATENIN; POTASSIUM CHANNEL; SOMATIC MUTATIONS; aldosterone-producing adenoma; calcium signalling; glomerulosa cell; membrane potential; primary aldosteronism |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 11 Sep 2020 06:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1607 |
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