Ignatov, T. and Poehlmann, A. and Ignatov, A. and Schinlauer, A. and Costa, S. D. and Roessner, A. and Kalinski, T. and Bischoff, J. (2013) BRCA1 promoter methylation is a marker of better response to anthracycline-based therapy in sporadic TNBC. BREAST CANCER RESEARCH AND TREATMENT, 141 (2). pp. 205-212. ISSN 0167-6806,
Full text not available from this repository. (Request a copy)Abstract
The aim of the current study was to investigate the role of BRCA1 gene aberrations in sporadic triple-negative breast cancer (TNBC) and its impact on anthracycline-based therapy. BRCA1 promoter methylation was analyzed in 70 TNBC and compared with the clinical and pathologic characteristics. As a control group, we used 70 patients with non-TNBC. BRCA1 promoter methylation was observed in 65.2 % of patients and was similar in both groups. BRCA1 promoter methylation was associated with decreased intensity of BRCA1 protein expression (P = 0.002) and significant increase of median disease-free survival (DFS) of TNBC patients receiving adjuvant anthracycline-based chemotherapy (P = 0.001). Multivariate analysis revealed that BRCA1 promoter methylation remains a favorable factor in regard to DFS (HR 0.224; 95 % CI 0.092-0.546, P = 0.001) in TNBC after adjustment for other prognostic factors. In contrast, in non-TNBC, BRCA1 promoter methylation was not associated with any clinical and pathologic parameters. BRCA1 promoter methylation is a common mechanism of BRCA1 gene aberration in sporadic breast cancer and is predictive for better response to anthracycline-based therapies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEGATIVE BREAST-CANCER; RNA EXPRESSION LEVELS; NEOADJUVANT CHEMOTHERAPY; CHEMOSENSITIVITY; MUTATION; SENSITIVITY; CISPLATIN; TUMORS; CELLS; Breast cancer; BRCA1; Promoter methylation; TNBC |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Apr 2020 06:52 |
| Last Modified: | 01 Apr 2020 06:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16118 |
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