Oswald, Mira and Geissler, Simon and Goepferich, Achim (2017) Targeting the Central Nervous System (CNS): A Review of Rabies Virus-Targeting Strategies. MOLECULAR PHARMACEUTICS, 14 (7). pp. 2177-2196. ISSN 1543-8384
Full text not available from this repository. (Request a copy)Abstract
The transport of drugs across the blood-brain barrier is challenging. The use of peptide sequences derived from viruses with a central nervous system (CNS) tropism is one elegant option. A prominent example is the rabies virus glycopeptide-29 (RVG-29), which is said to enable a targeted brain delivery. Although the entry mechanism of the rabies virus into the CNS is very well characterized, it is unknown whether RVG-29-functionalized drug delivery systems (DDSs) follow this pathway. RVG-29-functionalized DDSs present themselves with modifications of the RVG-29 peptide sequence and different physicochemical properties compared to the rabies virus. To our surprise, the impact of these changes on the functionality is completely neglected. This review explores virus-related CNS-targeting strategies by comparing RVG-29-fonctronalized DDSs with regard to their peptide modification, physiochemical properties and their behavior in cell culture studies with a special focus on the original pathway of rabies virus entry into the CNS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BLOOD-BRAIN-BARRIER; NICOTINIC ACETYLCHOLINE-RECEPTORS; P75 NEUROTROPHIN RECEPTOR; DYNEIN LIGHT-CHAIN; CELLS IN-VITRO; SIRNA DELIVERY; GENE DELIVERY; MOUSE-BRAIN; RETROGRADE TRANSPORT; GLYCOPROTEIN RVG29; CNS-targeting strategies; rabies virus glycopeptide; blood-brain barrier |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 10 Sep 2020 09:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1613 |
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