Fendt, Markus and Imobersteg, Stefan and Peterlik, Daniel and Chaperon, Frederique and Mattes, Catherine and Wittmann, Christina and Olpe, Hans-Rudolf and Mosbacher, Johannes and Vranesic, Ivo and van der Putten, Herman and McAllister, Kevin H. and Flor, Peter J. and Gee, Christine E. (2013) Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology. NEUROPHARMACOLOGY, 72. pp. 215-223. ISSN 0028-3908,
Full text not available from this repository. (Request a copy)Abstract
Glutamate transmission and synaptic plasticity in the amygdala are essential for the learning and expression of conditioned fear. Glutamate activates both ionotropic glutamate receptors and eight subtypes of metabotropic glutamate receptors (mGlu(1-8)). In the present study, we investigated the roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and synaptic plasticity. We show that ablation of mGlu(7) but not mGlu(8) attenuates long-term potentiation (LTP) at thalamo-lateral amygdala (LA) synapses where a strong association between LTP and learning has been demonstrated. mGlu(7)-deficient mice express a general deficit in conditioned fear whereas mGlu(8)-deficient mice show a dramatic reduction in contextual fear. The mGlu(7) agonist AMN082 reduced thalamo-LA LTP and intra-amygdala administration blocked conditioned fear learning. In contrast, the mGlu(8) agonist DCPG decreased synaptic transmission but not LTP at thalamo-LA synapses. Intra-amygdala DCPG selectively reduced the expression of contextual fear but did not affect the acquisition and expression of cued fear. Taken together, these data revealed very different roles for mGlu(7) and mGlu(8) in amygdala synaptic transmission, fear learning and its expression. These receptors seem promising targets for treating anxiety disorders with different underlying pathologies with exaggerated fear learning (mGlu(7)) or contextual fear (mGlu(8)). (C) 2013 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | METABOTROPIC GLUTAMATE-RECEPTOR; FEAR-POTENTIATED STARTLE; LONG-TERM POTENTIATION; CONDITIONED FEAR; KNOCKOUT MICE; BASOLATERAL AMYGDALA; AGONIST (S)-3,4-DCPG; ANXIETY DISORDER; SUBTYPE 7; EXTINCTION; AMN082; Anxiety; Contextual fear; DCPG; Fear learning; Glutamate |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Molecular and Cellular Neurobiology (Prof. Dr. Peter J. Flor) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Apr 2020 09:38 |
| Last Modified: | 02 Apr 2020 09:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16167 |
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