Sontag, Thomas-A. and Fuermaier, Anselm B. M. and Hauser, Joachim and Kaunzinger, Ivo and Tucha, Oliver and Lange, Klaus W. (2013) Spatial Memory in Spontaneously Hypertensive Rats (SHR). PLOS ONE, 8 (8): e74660. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
The spontaneously hypertensive rat (SHR) is an established animal model of ADHD. It has been suggested that ADHD symptoms arise from deficits in executive functions such as working memory, attentional control and decision making. Both ADHD patients and SHRs show deficits in spatial working memory. However, the data on spatial working memory deficits in SHRs are not consistent. It has been suggested that the reported cognitive deficits of SHRs may be related to the SHRs' locomotor activity. We have used a holeboard (COGITAT) to study both cognition and activity in order to evaluate the influence of the activity on the cognitive performance of SHRs. In comparison to Wistar-Kyoto (WKY) rats, SHRs did not have any impairment in spatial working memory and reference memory. When the rats' locomotor activity was taken into account, the SHRs' working memory and reference memory were significantly better than in WKY rats. The locomotor activity appears to be a confounding factor in spatial memory tasks and should therefore be controlled for in future studies. In the SHR model of ADHD, we were unable to demonstrate an impairment of working memory which has been reported in patients with ADHD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATTENTION-DEFICIT/HYPERACTIVITY-DISORDER; DEFICIT HYPERACTIVITY DISORDER; CENTRAL NICOTINIC RECEPTORS; ANIMAL-MODEL; COGNITIVE IMPAIRMENT; WORKING-MEMORY; WISTAR-KYOTO; PERFORMANCE; AMPHETAMINE; DOPAMINE; |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Apr 2020 05:20 |
| Last Modified: | 03 Apr 2020 05:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16213 |
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