May, Matthias and Burger, Maximilian and Otto, Wolfgang and Hakenberg, Oliver W. and Wieland, Wolf F. and May, Dieter and Hofstaedter, Ferdinand and Goetz, Stefanie and Niessl, Nina and Fritsche, Hans-Martin and Birnkammer, Kristina and Gilfrich, Christian and Peter, Julia and Jain, Anjun and Koch, Stefan and Lebentrau, Steffen and Riedmiller, Hubertus and Roessler, Wolfgang and Denzinger, Stefan and Brookman-May, Sabine and Gunia, Sven (2013) Ki-67, mini-chromosome maintenance 2 protein (MCM2) and geminin have no independent prognostic relevance for cancer-specific survival in surgically treated squamous cell carcinoma of the penis. BJU INTERNATIONAL, 112 (4). E383-E390. ISSN 1464-4096, 1464-410X
Full text not available from this repository. (Request a copy)Abstract
Objective To assess the role of cell proliferation-associated biomarkers to predict cancer-specific survival (CSS) in patients with surgically treated squamous cell carcinoma of the penis (SCCP). Patients and Methods A multicentre study enrolling 158 consecutive patients with surgically treated SCCP was performed. After conducting a central histopathological review, the staining profiles of Ki-67, mini-chromosome maintenance 2 protein (MCM2) and geminin were evaluated for their correlation with conventional histopathological criteria and their prognostic relevance for predicting CSS in a multivariable Cox proportional hazards regression model (median [interquartile range] follow-up 33[6-63] months). Results Staining evaluation showed high interobserver agreement (92-96%). Ki-67 and MCM2 displayed a significant positive correlation with histological tumour grade, lymphovascular invasion (LVI) and nodal status, whereas geminin expression only correlated with tumour grade. The 5-year CSS for the entire study cohort was 62%. Univariable analysis showed a significant prognostic impact of Ki-67 (P = 0.026), MCM2 (P = 0.007), and geminin (P = 0.036). In multivariable analysis, only pT (hazard ratio [HR] 1.67; P = 0.003) and pN stage (HR 2.62; P = 0.015) as well as tumour grade (HR 1.89; P = 0.036) and LVI (HR 2.66; P = 0.028) were identified as independent prognostic parameters for CSS. The accuracy of the Cox model for CSS prediction was 0.820 (95% confidence interval 0.741-0.898). Conclusions At present, conventional histopathological criteria remain the most powerful predictors of CSS in surgically treated SCCP. Due to overlapping staining profiles, Ki-67, MCM2 and geminin, either singly or in various combinations, failed to immunohistochemically refine the boundaries between Broders' grading categories. Ki-67, MCM2 and geminin do not represent independent prognostic parameters but reflect a more aggressive behaviour in surgically treated SCCP. Further studies are needed to clarify the currently contradictory predictive role of proliferation-associated biomarkers in terms of predicting nodal involvement in SCCPs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CYCLIN D1; EXPRESSION; INVOLVEMENT; P53; squamous cell carcinoma of the penis (SCCP); immunohistochemistry; proliferation-related biomarkers; Ki-67; mini-chromosome maintenance 2 protein (MCM2); geminin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Apr 2020 12:39 |
| Last Modified: | 02 Apr 2020 12:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16258 |
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