Bandulik, Sascha and Tauber, Philipp and Penton, David and Schweda, Frank and Tegtmeier, Ines and Sterner, Christina and Lalli, Enzo and Lesage, Florian and Hartmann, Michaela and Barhanin, Jacques and Warth, Richard (2013) Severe Hyperaldosteronism in Neonatal Task3 Potassium Channel Knockout Mice Is Associated With Activation of the Intraadrenal Renin-Angiotensin System. ENDOCRINOLOGY, 154 (8). pp. 2712-2722. ISSN 0013-7227,
Full text not available from this repository. (Request a copy)Abstract
Task3 K+ channels are highly expressed in the adrenal cortex and contribute to the angiotensin II and K+ sensitivity of aldosterone-producing glomerulosa cells. Adult Task3(-/-) mice display a partially autonomous aldosterone secretion, subclinical hyperaldosteronism, and salt-sensitive hypertension. Here, we investigated the age dependence of the adrenal phenotype of Task3(-/-) mice. Compared with adults, newborn Task3(-/-) mice displayed a severe adrenal phenotype with strongly increased plasma levels of aldosterone, corticosterone, and progesterone. This adrenocortical dysfunction was accompanied by a modified gene expression profile. The most strongly up-regulated gene was the protease renin. Real-time PCR corroborated the strong increase in adrenal renin expression, and immunofluorescence revealed renin-expressing cells in the zona fasciculata. Together with additional factors, activation of the local adrenal renin system is probably causative for the severely disturbed steroid hormone secretion of neonatal Task3(-/-) mice. The changes in gene expression patterns of neonatal Task3(-/-) mice could also be relevant for other forms of hyperaldosteronism.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN ADRENOCORTICAL-CELLS; DEPENDENT SIGNALING CASCADE; RAT ADRENAL-GLAND; ALDOSTERONE SECRETION; GLOMERULOSA CELLS; ZONA-GLOMERULOSA; BLOOD-PRESSURE; HYPERTENSION; EXPRESSION; GALANIN; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Richard Warth Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Apr 2020 08:29 |
| Last Modified: | 03 Apr 2020 08:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16281 |
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