Karger, Christian and Kurtz, Felix and Steppan, Dominik and Schwarzensteiner, Ilona and Machura, Katharina and Angel, Peter and Banas, Bernhard and Risteli, Juha and Kurtz, Armin (2013) Procollagen I-expressing renin cell precursors. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 305 (3). F355-F361. ISSN 1931-857X,
Full text not available from this repository. (Request a copy)Abstract
Renin-expressing cells in the kidney normally appear as mural cells of developing preglomerular vessels and finally impose as granulated juxtaglomerular cells in adult kidneys. The differentiation of renin-expressing cells from the metanephric mesenchyme in general and the potential role of special precursor stages in particular is not well understood. Therefore, it was the aim of this study to search for renin cell precursors in the kidney. As an experimental model, we used kidneys of aldosterone synthase-deficient mice, which display a prominent compensatory overproduction of renin cells that are arranged in multilayered perivascular cell clusters. We found that the perivascular cell clusters contained two apparently distinct cell types, one staining positive for renin and another one staining positive for type I procollagen (PC1). It appeared as if PC1 and renin expression were inversely related at the cellular level. The proportion of renin-positive to PC1-positive cells in the clusters was inversely linked to the rate of salt intake, as was overall renin expression. Our findings suggest that the cells in the perivascular cell clusters can reversibly switch between PC1 and renin expression and that PC1-expressing cells might be precursors of renin cells. A few of those PC1-positive cells were found also in adult wild-type kidneys in the juxtaglomerular lacis cell area, in which renin expression can be induced on demand.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | KIDNEY; MICE; ALDOSTERONE; HYPERPLASIA; HOMEOSTASIS; PHENOTYPE; RESPONSES; renin; procollagen; juxtaglomerular cell |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Apr 2020 13:18 |
| Last Modified: | 03 Apr 2020 13:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16288 |
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