Klein, A. and Buschmann, M. and Babilas, P. and Landthaler, M. and Baeumler, W. (2013) Indocyanine green-augmented diode laser therapy vs. long-pulsed Nd:YAG (1064 nm) laser treatment of telangiectatic leg veins: a randomized controlled trial. BRITISH JOURNAL OF DERMATOLOGY, 169 (2). pp. 365-373. ISSN 0007-0963,
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Background Telangiectatic leg veins (TLV) represent a common cosmetic problem. Near infrared lasers have been widely used in treatment because of their deeper penetration into the dermis, but with varying degrees of success, particularly because of different vessel diameters. Indocyanine green (ICG)-augmented diode laser treatment (ICG+DL) may present an alternative treatment option. Objectives This trial evaluates the efficacy of ICG+DL in the treatment of TLV and compares the safety and efficacy of therapy with the standard treatment, the long-pulsed neodymium-doped yttrium aluminium garnet (Nd:YAG) laser. Methods In a prospective randomized controlled clinical trial, 29 study participants with TLV were treated with a Nd:YAG laser ((em)=1064nm, 160-240Jcm(-2), 65-ms pulse duration, 5-mm spot size) and ICG+DL ((em)=810nm, 60-110Jcm(-2), 48-87-ms pulse duration, 6-mm spot size; total ICG dose 4mgkg(-1)) in a side-by-side comparison in one single treatment setting that included histological examination in four participants. Two blinded investigators and the participants assessed clearance rate, cosmetic appearance and adverse events up to 3months after treatment. Results According to both the investigators' and participants' assessment, clearance rates were significantly better after ICG+DL therapy than after Nd:YAG laser treatment (P<005). On a 10-point scale indicating pain during treatment, participants rated ICG+DL therapy to be more painful (61 +/- 20) than Nd:YAG laser (54 +/- 20). Conclusions ICG+DL therapy represents a new and promising treatment modality for TLV, with high clearance rates and a very good cosmetic outcome after one single treatment session.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ND-YAG LASER; PORT-WINE STAINS; LOWER-EXTREMITY TELANGIECTASES; RETICULAR VEINS; BLOOD-VESSELS; ABSORPTION; MM; PHOTOTHERMOLYSIS; SCLEROTHERAPY; VENULECTASIAS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Apr 2020 13:20 |
| Last Modified: | 03 Apr 2020 13:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16289 |
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