Luchner, Andreas and Behrens, Gundula and Stritzke, Jan and Markus, Marcello and Stark, Klaus and Peters, Annette and Meisinger, Christa and Leitzmann, Michael and Hense, Hans-Werner and Schunkert, Heribert and Heid, Iris M. (2013) Long-term pattern of brain natriuretic peptide and N-terminal pro brain natriuretic peptide and its determinants in the general population: contribution of age, gender, and cardiac and extra-cardiac factors. EUROPEAN JOURNAL OF HEART FAILURE, 15 (8). pp. 859-867. ISSN 1388-9842, 1879-0844
Full text not available from this repository. (Request a copy)Abstract
Aims The natriuretic peptides BNP and NT-proBNP are potent cardiac markers, but knowledge of long-term changes is sparse. We thus quantified determinants of change in BNP and NT-proBNP in a study of south German residents (KORA). Methods and results A total of 1005 men and women (age 25-74 years, mean 48 years) underwent physical examination and echocardiography at baseline and at follow-up after 10 years. The current analysis comprised 877 subjects with dual measurements of BNP and NT-proBNP. Both markers increased in both sexes (P < 0.001) during the 10-year follow-up, and higher levels in women persisted across time (P for sex difference < 0.001). Among baseline covariates, predictors for 10-year change of NT-proBNP, BNP, or both were age, sex, diabetes status, and heart rate (multivariable regression analysis, each P < 0.05). However, changes of covariates over the 10-year follow-up were much stronger determinants. Specifically, incident myocardial infarction, new beta-blocker medication, and increased cardiac parameters (left atrial diameter, LV end-diastolic diameter, and LV mass index) were associated with increasing BNP, NT-proBNP, or both, whereas increased heart rate, haematocrit, and body mass index (BMI) were associated with decreasing BNP and NT-proBNP (all P < 0.05). Conclusion Next to ageing and sex, a variety of changes in covariates reflecting the sequelae of cardiac remodelling as well as myocardial infarction and diabetes influence long-term changes of BNP and NT-proBNP. Of note, diabetes and increased BMI exert opposite effects. For interpretation of individual marker concentrations, a host of covariates needs to be considered, especially in subjects without prevalent or incident cardiac disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LEFT-VENTRICULAR DYSFUNCTION; HEART-FAILURE; INDEPENDENT PREDICTOR; SYSTOLIC DYSFUNCTION; RISK-FACTOR; BNP; DIAGNOSIS; OBESITY; IMPACT; HYPERTROPHY; 10-year-follow-up; Hypertension; Natriuretic peptides; Echocardiography; LV hypertrophy; Heart failure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 06:14 |
| Last Modified: | 06 Apr 2020 06:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16301 |
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