Gosau, Martin and Buergers, Ralf and Vollkommer, Tobias and Holzmann, Thomas and Prantl, Lukas (2013) Effectiveness of antibacterial copper additives in silicone implants. JOURNAL OF BIOMATERIALS APPLICATIONS, 28 (2). pp. 187-198. ISSN 0885-3282, 1530-8022
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Staphylococcus epidermidis plays a major role in capsular contractures of silicone breast implants. This invitro study evaluates the antibacterial effect of copper on S. epidermidis in silicone implants. Specimens of a silicone material used for breast augmentation (Cu0) and specimens coated with different copper concentrations (Cu1, Cu2) were artificially aged. Surface roughness and surface free energy were assessed. The specimens were incubated in an S. epidermidis suspension. We assessed the quantification and the viability of adhering bacteria by live/dead cell labeling with fluorescence microscopy. Additionally, inhibition of bacterial growth was evaluated by agar diffusion, broth culture, and quantitative culture of surface bacteria. No significant differences in surface roughness and surface free energy were found between Cu0, Cu1 and Cu2. Aging did not change surface characteristics and the extent of bacterial adhesion. Fluorescence microscopy showed that the quantity of bacteria on Cu0 was significantly higher than that on Cu1 and Cu2. The ratio of dead to total adhering bacteria was significantly lower on Cu0 than on Cu1 and Cu2, and tended to be higher for Cu2 than for Cu1. Quantitative culture showed equal trends. Copper additives seem to have anti-adherence and bactericidal effects on S. epidermidis invitro.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SURFACE-FREE-ENERGY; OF-THE-LITERATURE; CAPSULAR CONTRACTURE; STAPHYLOCOCCUS-EPIDERMIDIS; BIOFILM FORMATION; BREAST IMPLANT; BACTERIAL ADHESION; AUGMENTATION MAMMAPLASTY; STREPTOCOCCUS-MUTANS; ENTEROCOCCUS-FAECIUM; Silicone implants; copper additives; Staphyolcoccus epidermidis; implant infection; capsular contracture; antibacterial effect |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Zahnärztliche Prothetik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 06:27 |
| Last Modified: | 06 Apr 2020 06:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16305 |
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