Eggenhofer, Elke and Popp, Felix C. and Mendicino, Michael and Silber, Paula and van't Hof, Wouter and Renner, Philipp and Hoogduijn, Martin J. and Pinxteren, Jef and van Rooijen, Nico and Geissler, Edward K. and Deans, Robert and Schlitt, Hans J. and Dahlke, Marc H. (2013) Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression. STEM CELLS TRANSLATIONAL MEDICINE, 2 (8). pp. 595-606. ISSN 2157-6564, 2157-6580
Full text not available from this repository. (Request a copy)Abstract
Multipotent adult progenitor cells (MAPCs) are an adherent stem cell population that belongs to the mesenchymal-type progenitor cell family. Although MAPCs are emerging as candidate agents for immunomodulation after solid organ transplantation, their value requires further validation in a clinically relevant cell therapy model using an organ donor- and organ recipient-independent, third-party cell product. We report that stable allograft survival can be achieved following third-party MAPC infusion in a rat model of fully allogeneic, heterotopic heart transplantation. Furthermore, long-term accepted heart grafts recovered from MAPC-treated animals can be successfully retransplanted to naive animals without additional immunosuppression. This prolongation of MAPC-mediated allograft acceptance depends upon a myeloid cell population since depletion of macrophages by clodronate abrogates the tolerogenic MAPC effect. We also show that MAPC-mediated allograft acceptance differs mechanistically from drug-induced tolerance regarding marker gene expression, T regulatory cell induction, retransplantability, and macrophage dependence. MAPC-based immunomodulation represents a promising pathway for clinical immunotherapy that has led us to initiate a phase I clinical trial for testing safety and feasibility of third-party MAPC therapy after liver transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESENCHYMAL STEM-CELLS; RENAL-TRANSPLANT TOLERANCE; REGULATORY T-CELLS; BONE-MARROW; MEDIATED IMMUNOSUPPRESSION; MYOCARDIAL-INFARCTION; ALLOGRAFT TOLERANCE; CARDIAC ALLOGRAFTS; STROMAL CELLS; RAT; Immunosuppression; Mesenchymal stem cells; Transplantation; T cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 06:39 |
| Last Modified: | 06 Apr 2020 06:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16308 |
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