Schecklmann, Martin and Ehlis, Ann-Christine and Plichta, Michael M. and Dresler, Thomas and Heine, Monika and Boreatti-Huemmer, Andrea and Romanos, Marcel and Jacob, Christian and Pauli, Paul and Fallgatter, Andreas J. (2013) Working Memory and Response Inhibition as One Integral Phenotype of Adult ADHD? A Behavioral and Imaging Correlational Investigation. JOURNAL OF ATTENTION DISORDERS, 17 (6). pp. 470-482. ISSN 1087-0547, 1557-1246
Full text not available from this repository. (Request a copy)Abstract
Objective: It is an open question whether working memory (WM) and response inhibition (RI) constitute one integral phenotype in attention deficit hyperactivity disorder (ADHD). Method: The authors investigated 45 adult ADHD patients and 41 controls comparable for age, gender, intelligence, and education during a letter n-back and a stop-signal task, and measured prefrontal oxygenation by means of functional near-infrared spectroscopy. Results: The authors replicated behavioral and cortical activation deficits in patients compared with controls for both tasks and also for performance in both control conditions. In the patient group, 2-back performance was correlated with stop-signal reaction time. This correlation did not seem to be specific for WM and RI as 1-back performance was correlated with go reaction time. No significant correlations of prefrontal oxygenation between WM and RI were found. Conclusion: The authors' findings do not support the hypothesis of WM and RI representing one integral phenotype of ADHD mediated by the prefrontal cortex.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; NEAR-INFRARED SPECTROSCOPY; DEFICIT HYPERACTIVITY DISORDER; STOP-SIGNAL; METAANALYSIS; PERFORMANCE; IMPULSIVITY; CHILDREN; VALIDITY; MOTOR; ADHD; n-back; stop signal; near-infrared spectroscopy; impulsivity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 07:08 |
| Last Modified: | 06 Apr 2020 07:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16316 |
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