Seitz, Roswitha and Ohlmann, Andreas and Tamm, Ernst R. (2013) The role of Muller glia and microglia in glaucoma. CELL AND TISSUE RESEARCH, 353 (2). pp. 339-345. ISSN 0302-766X, 1432-0878
Full text not available from this repository. (Request a copy)Abstract
Cells of Muller glia and microglia react to neuronal injury in glaucoma. The change to a reactive phenotype initiates signaling cascades that may serve a neuroprotective role, but may also proceed to promote damaging effects on retinal neurons. Both effects appear to occur most likely in parallel in glaucoma, but the underlying mechanisms and signaling pathways that specifically promote protective versus destructive roles of reactive glial cells are mostly unclear. More research is needed to understand the homeostatic signaling network in which retinal glia cells are embedded to maintain or restore neuronal function after injury.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RETINAL GANGLION-CELLS; TUMOR-NECROSIS-FACTOR; CILIARY NEUROTROPHIC FACTOR; OPTIC-NERVE HEAD; LEUKEMIA INHIBITORY FACTOR; FIBRILLARY ACIDIC PROTEIN; NITRIC-OXIDE PRODUCTION; MOUSE MODEL; UP-REGULATION; IN-VIVO; Glaucoma; Microglia; Muller glia; Neuroprotection; Retina |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Jun 2020 11:00 |
| Last Modified: | 16 Jun 2020 11:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16322 |
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