Dimethyl fumarate: a Janus-faced substance?

Kees, Frieder (2013) Dimethyl fumarate: a Janus-faced substance? EXPERT OPINION ON PHARMACOTHERAPY, 14 (11). pp. 1559-1567. ISSN 1465-6566, 1744-7666

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Abstract

Introduction: Dimethyl fumarate (DMF) has been used as fungicide, but oral DMF activates anti-inflammatory and anti-oxidative pathways that are beneficial in the treatment of psoriasis. BG-12, a specific formulation of DMF, has been approved very recently for the treatment of relapsing-remitting multiple sclerosis (RRMS), which is characterized by both autoimmune lymphocytes leading to inflammation and mitochondrial alterations associated with oxidative stress. Areas covered: This review describes the pharmacokinetics and the mode of action of DMF, with a focus on molecular and cellular pathways, and discusses clinical results of DMF in RRMS treatment. To identify relevant publications, the author searched the PubMed database by using appropriate keywords and by searching for references cited within the obtained articles. Expert opinion: DMF demonstrated efficacy in several RRMS outcome measures related to disease activity and severity, but results on disability progression have been inconsistent. The overall safety profile might qualify DMF for long-term use, the frequency of side effects such as gastrointestinal complaints and flushing might hamper treatment adherence of MS patients. Since DMF covalently binds to intracellular proteins, the fate of this molecule in the body might need thorough long-term observation during clinical use.

Item Type: Article
Uncontrolled Keywords: REMITTING MULTIPLE-SCLEROSIS; PLACEBO-CONTROLLED PHASE-3; LONG-TERM TREATMENT; ACID-ESTERS; DOUBLE-BLIND; GLUTATHIONE DEPLETION; ENDOTHELIAL-CELLS; SYSTEMIC THERAPY; OXIDATIVE STRESS; HEME OXYGENASE-1; BG-12; dimethyl fumarate; mode of action; multiple
Subjects: 600 Technology > 615 Pharmacy
Divisions: Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Frieder Kees
Depositing User: Petra Gürster
Date Deposited: 16 Jun 2020 11:16
Last Modified: 16 Jun 2020 11:16
URI: https://pred.uni-regensburg.de/id/eprint/16324

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