Ganzer, Roman and Fritsche, Hans-Martin and Brandtner, Andreas and Bruendl, Johannes and Koch, Daniel and Wieland, Wolf F. and Blana, Andreas (2013) Fourteen-year oncological and functional outcomes of high-intensity focused ultrasound in localized prostate cancer. BJU INTERNATIONAL, 112 (3). pp. 322-329. ISSN 1464-4096,
Full text not available from this repository. (Request a copy)Abstract
Objective To assess the safety, functional and oncological long-term outcomes of high-intensity focused ultrasound (HIFU) as a primary treatment option for localized prostate cancer (PCa). Patients and Methods We conducted a retrospective single-centre study on 538 consecutive patients who underwent primary HIFU for clinically localized PCa between November 1997 and September 2009. Factors assessed were: biochemical disease-free survival (BDFS) according to Phoenix criteria (prostate-specific antigen nadir + 2 ng/mL); metastatic-free, overall and PCa-specific survival; salvage treatment; side effects; potency; and continence status. Results The mean (SD; range) follow-up was 8.1 (2.9; 2.1-14.0) years. The actuarial BDFS rates at 5 and 10 years were 81 and 61%, respectively. The 5-year BDFS rates for low-, intermediate- and high-risk patients were 88, 83 and 48%, while the 10-year BDFS rates were 71, 63 and 32%, respectively. Metastatic disease was reported in 0.4, 5.7 and 15.4% of low-, intermediate- and high-risk patients, respectively. The salvage treatment rate was 18%. Seventy-five (13.9%) patients died. PCa-specific death was registered in 18 (3.3%) patients (0, 3.8 and 11% in the low-, intermediate- and high-risk groups, respectively). Side effects included bladder outlet obstruction (28.3%), Grade I, II and III stress urinary incontinence (13.8, 2.4 and 0.7%, respectively) and recto-urethral fistula (0.7%). Preserved potency was 25.4% (in previously potent patients). Conclusions The study demonstrates the efficacy and safety of HIFU for localized PCa. HIFU is a therapeutic option for patients of advanced age, in the low- or intermediate- risk groups, and with a life expectancy of similar to 10 years.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEFINING BIOCHEMICAL FAILURE; RADICAL PROSTATECTOMY; TRANSRECTAL HIFU; RADIOTHERAPY; THERAPY; HIFU; localized; long-term; outcome; prostate cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 10:36 |
| Last Modified: | 06 Apr 2020 10:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16331 |
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