Treeck, Oliver and Schueler, Susanne and Haering, Julia and Skrzypczak, Maciej and Lattrich, Claus and Ortmann, Olaf (2013) icb-1 Gene counteracts growth of ovarian cancer cell lines. CANCER LETTERS, 335 (2). pp. 441-446. ISSN 0304-3835,
Full text not available from this repository. (Request a copy)Abstract
Human gene icb-1 has been originally identified to be involved in differentiation processes of cancer cells. To examine the function of icb-1 in ovarian cancer, we knocked down its expression in three ovarian cancer cell lines and performed microarray-based gene expression profiling with subsequent gene network modeling. Loss of icb-1 expression accelerated proliferation of SK-OV-3, OVCAR-3 and OAW-42 cells and led to upregulation of ovarian cancer biomarkers like KLK10 and CLDN16. Most of the upregulated genes were part of oncogenic pathways regulated by ER alpha, or TNF. Our data suggest that icb-1 gene inhibits growth and progression of ovarian cancer cells. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SINGLE NUCLEOTIDE POLYMORPHISMS; ESTROGEN-RECEPTOR; EPITHELIAL-CELLS; EXPRESSION; BREAST; DIFFERENTIATION; OVEREXPRESSION; PROLIFERATION; ACTIVATION; SURVIVAL; Transcriptome analysis; icb-1 Gene; Gene knockdown; Ovarian cancer; Gene expression profiling |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 07:21 |
| Last Modified: | 06 Apr 2020 07:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16349 |
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