Melnik, Bodo C. and John, Swen Malte and Schmitz, Gerd (2013) Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. NUTRITION JOURNAL, 12: 103. ISSN 1475-2891
Full text not available from this repository. (Request a copy)Abstract
Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up-regulation by milk consumption. This review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) for mTORC1 activation. Importantly, milk exosomes, which regularly contain microRNA-21, most likely represent a genetic transfection system enhancing mTORC1-driven metabolic processes. Whereas human breast milk is the ideal food for infants allowing appropriate postnatal growth and species-specific metabolic programming, persistent high milk signaling during adolescence and adulthood by continued cow's milk consumption may promote mTORC1-driven diseases of civilization.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PANCREATIC BETA-CELLS; BRANCHED-CHAIN AMINO; I IGF-I; IMMUNE-RELATED MICRORNAS; FACTOR-BINDING PROTEIN-1; MAMMALIAN TARGET; INSULIN-RESISTANCE; COMPLEX 1; INTERCELLULAR COMMUNICATION; GLUTAMATE-DEHYDROGENASE; Branched-chain amino acids; Diseases of civilization; Glucose-dependent insulinotropic polypeptide; Glucagon-like peptide-1; Exosomal microRNA; Leucine; MicroRNA-21; Milk; mTORC1; Postnatal growth; Tryptophan |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 Jun 2020 07:52 |
| Last Modified: | 18 Jun 2020 07:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16351 |
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