Alichniewicz, K. K. and Brunner, E. and Kluenemann, H. H. and Greenlee, M. W. (2013) Neural correlates of saccadic inhibition in healthy elderly and patients with amnestic mild cognitive impairment. FRONTIERS IN PSYCHOLOGY, 4: 467. ISSN 1664-1078,
Full text not available from this repository. (Request a copy)Abstract
Performance on tasks that require saccadic inhibition declines with age and altered inhibitory functioning has also been reported in patients with Alzheimer's disease. Although mild cognitive impairment (MCI) is assumed to be a high-risk factor for conversion to AD, little is known about changes in saccadic inhibition and its neural correlates in this condition. Our study determined whether the neural activation associated with saccadic inhibition is altered in persons with amnestic mild cognitive impairment (aMCI). Functional magnetic resonance imaging (fMRI) revealed decreased activation in parietal lobe in healthy elderly persons compared to young persons and decreased activation in frontal eye fields in aMCI patients compared to healthy elderly persons during the execution of anti-saccades. These results illustrate that the decline in inhibitory functions is associated with impaired frontal activation in aMCI. This alteration in function might reflect early manifestations of AD and provide new insights in the neural activation changes that occur in pathological ageing.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EVENT-RELATED FMRI; ANTISACCADE TASK-PERFORMANCE; LATENT-VARIABLE ANALYSIS; FRONTAL EYE FIELDS; ADULT LIFE-SPAN; ALZHEIMERS-DISEASE; BRAIN ACTIVITY; EXECUTIVE FUNCTIONS; WORKING-MEMORY; NEUROPATHOLOGICAL PROFILE; mild cognitive impairment; Alzheimer's disease (AD); ageing; inhibition functions; anti-saccades; fMRI |
| Subjects: | 100 Philosophy & psychology > 150 Psychology 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 07:29 |
| Last Modified: | 06 Apr 2020 07:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16354 |
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