Borisow, Nadja and Kleiter, Ingo and Gahlen, Anna and Fischer, Katrin and Wernecke, Klaus-Dieter and Pache, Florence and Ruprecht, Klemens and Havla, Joachim and Krumbholz, Markus and Kuempfel, Tania and Aktas, Orhan and Ringelstein, Marius and Geis, Christian and Kleinschnitz, Christoph and Berthele, Achim and Hemmer, Bernhard and Angstwurm, Klemens and Weissert, Robert and Stellmann, Jan-Patrick and Schuster, Simon and Stangel, Martin and Lauda, Florian and Tumani, Hayrettin and Mayer, Christoph and Zeltner, Lena and Ziemann, Ulf and Linker, Ralf A. and Schwab, Matthias and Marziniak, Martin and Bergh, Florian Then and Hofstadt-van Oy, Ulrich and Neuhaus, Oliver and Winkelmann, Alexander and Marouf, Wael and Rueckriem, Lioba and Faiss, Juergen and Wildemann, Brigitte and Paul, Friedemann and Jarius, Sven and Trebst, Corinna and Hellwig, Kerstin (2017) Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. MULTIPLE SCLEROSIS JOURNAL, 23 (8). pp. 1092-1103. ISSN 1352-4585, 1477-0970
Full text not available from this repository. (Request a copy)Abstract
Background: Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases. Objective: To evaluate the impact of female sex and fertile age on aquaporin-4-antibody (AQP4-ab) status, attack localization, and response to attack treatment in patients with neuromyelitis optica (NMO) and its spectrum disorders (neuromyelitis optica spectrum disorder (NMOSD)). Methods: Female-to-male ratios, diagnosis at last visit (NMO vs NMOSD), attack localization, attack treatment, and outcome were compared according to sex and age at disease or attack onset. Results: A total of 186 NMO/SD patients (82% female) were included. In AQP4-ab-positive patients, female predominance was most pronounced during fertile age (female-to-male ratio 23:1). Female patients were more likely to be positive for AQP4-abs (92% vs 55%; p<0.001). Interval between onset and diagnosis of NMO/SD was longer in women than in men (mean 54 vs 27months; p=0.023). In women, attacks occurring 40years of age were more likely to show complete remission (p=0.003) and better response to high-dose intravenous steroids (p=0.005) compared to woman at >40years. Conclusion: Our data suggest an influence of sex and age on susceptibility to AQP4-ab-positive NMO/SD. Genetic and hormonal factors might contribute to pathophysiology of NMO/SD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYSTEMIC-LUPUS-ERYTHEMATOSUS; MULTIPLE-SCLEROSIS; IMMUNOLOGICAL FEATURES; EPIDEMIOLOGY; MULTICENTER; POPULATIONS; PHENOTYPE; RECOVERY; DISEASE; GENDER; Neuromyelitis optica; sex; age factors; aquaporin 4 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 20 Feb 2019 13:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1637 |
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