Dornia, Christian and Philip, Alois and Bauer, Stefan and Hoffstetter, Patrick and Lehle, Karla and Schmid, Christof and Lubnow, Matthias and Stroszczynski, Christian and Schreyer, Andreas G. (2013) Visualization of Thrombotic Deposits in Extracorporeal Membrane Oxygenation Devices Using Multidetector Computed Tomography: A Feasibility Study. ASAIO JOURNAL, 59 (4). pp. 439-441. ISSN 1058-2916, 1538-943X
Full text not available from this repository. (Request a copy)Abstract
Despite heparin coating and systemic anticoagulation, thrombotic clot formation is a serious complication in extracorporeal membrane oxygenation (ECMO). We describe our first results of visualization of thrombotic deposits in ECMO devices using advanced multidetector computed tomography (MDCT). A bioline-coated polymethylpentene membrane oxygenator (MO) after 8 days of ECMO treatment (device 1) and a factory-sealed MO serving as an internal quality control (device 2) were analyzed with three-dimensional (3D) visualization volume rendering technique (VRT) using a 0.6 mm(3) voxel isotropic MDCT dataset. After the computed tomography (CT) scan, device 1 was anatomically dissected for direct visualization of potential deposits and further analyzed by scanning electron microscopy (SEM). The VRT 3D model based on the MDCT dataset of device 1 showed red-coded areas within the gas exchange surface of the device consistent with fibrous and cellular deposits. These deposits could be confirmed by anatomical dissection of the device and by SEM. Device 2 showed no signs of clot formation in MDCT using the same VRT settings. It was demonstrated that MDCT with VRT is able to detect thrombotic deposits in ECMO devices under ex vivo conditions. MDCT allows direct visualization of the actual thrombus load of a used ECMO device as well as the quantification of the thrombus volume and could, therefore, play a significant role in better understanding the oxygenator thrombosis in modern ECMO treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; extracorporeal membrane oxygenation; multidetector computed tomography; volume rendering technique; thrombotic deposits |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 11:49 |
| Last Modified: | 06 Apr 2020 11:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16382 |
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