Tang, Zongxiang and Kim, Andrew and Masuch, Thorsten and Park, Kyoungsook and Weng, HaoJui and Wetzel, Christian and Dong, Xinzhong (2013) Pirt functions as an endogenous regulator of TRPM8. NATURE COMMUNICATIONS, 4: 2179. ISSN 2041-1723,
Full text not available from this repository. (Request a copy)Abstract
Pirt is a membrane protein that is specifically expressed in the peripheral nervous system, where it has been shown to increase the sensitivity of the transient receptor potential vanilloid 1 channel and modulate its role in heat pain. The broad expression of Pirt among dorsal root ganglion neurons suggests it may modulate other transient receptor potentials, such as the menthol and cooling sensor TRPM8. The discrepancies in the channel properties of TRPM8 in native neurons versus heterologous cells indicate the existence of endogenous modulators of the channel. Here we show that Pirt regulates the function of TRPM8 and its role in detecting cold. Pirt(-/-) mice exhibit decreased behavioural responses to cold and cool temperatures, and Pirt increases the sensitivity of TRPM8 to menthol and cool temperature. Our data suggest Pirt is an endogenous regulator of TRPM8.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INNOCUOUS COLD DISCRIMINATION; CHANNEL TRPM8; RECEPTOR; MENTHOL; IDENTIFICATION; SENSITIVITY; ACTIVATION; TEMPERATURE; STIMULI; HUMANS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 13:13 |
| Last Modified: | 06 Apr 2020 13:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16403 |
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