Schneider-Brachert, Wulf and Heigl, Ulrike and Ehrenschwender, Martin (2013) Membrane Trafficking of Death Receptors: Implications on Signalling. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 14 (7). pp. 14475-14503. ISSN 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Death receptors were initially recognised as potent inducers of apoptotic cell death and soon ambitious attempts were made to exploit selective ignition of controlled cellular suicide as therapeutic strategy in malignant diseases. However, the complexity of death receptor signalling has increased substantially during recent years. Beyond activation of the apoptotic cascade, involvement in a variety of cellular processes including inflammation, proliferation and immune response was recognised. Mechanistically, these findings raised the question how multipurpose receptors can ensure selective activation of a particular pathway. A growing body of evidence points to an elegant spatiotemporal regulation of composition and assembly of the receptor-associated signalling complex. Upon ligand binding, receptor recruitment in specialized membrane compartments, formation of receptor-ligand clusters and internalisation processes constitute key regulatory elements. In this review, we will summarise the current concepts of death receptor trafficking and its implications on receptor-associated signalling events.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; APOPTOSIS-INDUCING LIGAND; DOMAIN-CONTAINING RECEPTOR; TNF-LIKE LIGAND; HUMAN FAS LIGAND; CELL-DEATH; FACTOR-ALPHA; T-CELL; MEDIATED APOPTOSIS; death receptor; apoptosis; endocytosis; membrane trafficking; receptor internalisation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Jun 2020 10:49 |
| Last Modified: | 16 Jun 2020 10:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16411 |
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