Schoretsanitis, Georgios and Haen, Ekkehard and Stegmann, Benedikt and Hiemke, Christoph and Gruender, Gerhard and Paulzen, Michael (2017) Effect of smoking on risperidone pharmacokinetics - A multifactorial approach to better predict the influence on drug metabolism. SCHIZOPHRENIA RESEARCH, 185. pp. 51-57. ISSN 0920-9964, 1573-2509
Full text not available from this repository. (Request a copy)Abstract
Purpose: To disentangle an association between tobacco smoking, smoking habits and pharmacokinetic patterns such as plasma concentrations of risperidone (RIS), its active metabolite 9-hydroxyrisperidone (9-OH-RIS) and the active moiety, AM, (RIS + 9-OH-RIS) in a naturalistic sample. Methods: Plasma concentrations, dose adjusted plasma concentrations (C/D) of RIS, 9-OH-RIS and AM in patients out of a therapeutic drug monitoring (TDM) database were compared between smokers (n = 401) and nonsmokers (n = 292). Results: Daily dosage of risperidone differed significantly with smokers receiving higher doses than patients in the control group (p = 0.001). No differences were detected in plasma concentrations of the active moiety, RIS and 9-OH-RIS (p = 0.8 for AM, p = 0.646 for RIS and p = 0538 for 9-OH-RIS). However, dose corrected concentrations (C/D) of metabolite (C/D 9-OH-RIS) and active moiety (C/D AM) differed between significantly between groups (p = 0.002 and p = 0.007). After stratifying smokers to a group of moderate smokers (<20 cigarettes/clay) (RS1, n = 109) and a group of heavy smokers (>= 20 cigarettes clay) (RS2, n = 135), the comparison between non-smokers and both groups only showed lower values of C/D for 9-OH-RIS (p = 0.011) for the group of moderate smokers while other pharmacokinetic parameters did not differ. Conclusions: Apart from the well-known induction of CYP1A2 activity by polycyclic aromatic hydrocarbons, smoking might exert an effect on other CYP isoenzymes as well. A possible interpretation proposes a slight inducing effect of smoking on rispericlone metabolism most likely via CYP3A4. (C) 2016 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN CYTOCHROME-P450 ISOFORMS; TOBACCO SMOKING; CIGARETTE-SMOKING; IN-VITRO; SCHIZOPHRENIC-PATIENTS; PLASMA-CONCENTRATIONS; REDUCED HALOPERIDOL; CLOZAPINE; CYP2D6; 9-HYDROXYRISPERIDONE; Risperidone; Therapeutic drug monitoring; Cytochrome P450; Plasma concentration; Smoking; Pharmacokinetics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 15 Feb 2019 14:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1643 |
Actions (login required)
 |
View Item |
