Marx, Alexander and Pfister, Frederick and Schalke, Berthold and Saruhan-Direskeneli, Guher and Melms, Arthur and Stroebel, Philipp (2013) The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes. AUTOIMMUNITY REVIEWS, 12 (9). pp. 875-884. ISSN 1568-9972, 1873-0183
Full text not available from this repository. (Request a copy)Abstract
The thymus plays distinct roles in the pathogenesis of the different Myasthenia gravis (MG) subtypes. Inflammatory, neoplastic and age-related alterations of the thymus are of pivotal relevance for the initiation of antiacetylcholine receptor (AChR) autoimmunity in early onset MG, thymoma-associated MG and, likely, late onset MG, respectively. By contrast the thymus is presumably not related to MG that is due to autoantibodies to the muscle specific kinase, MuSK. Finally, the role of the thymus is still obscure in MG defined by antibodies against the agrin receptor LRP4 and in MG without all of the above autoantibdies (triple sero-negative MG) since these MG subtypes have been described only recently and thymectomy has not been their standard treatment This review aims to give an update on intrathymic mechanisms of tolerance breakdown in MG, including abnormal T cell selection and activation, the role of thymic myoid cells, the autoimmune regulator (AIRE) and regulatory T cells. (C) 2013 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; LATE-ONSET MYASTHENIA; ACETYLCHOLINE-RECEPTOR ANTIBODIES; MAIN IMMUNOGENIC REGION; SYNDROME TYPE-I; EPITHELIAL-CELLS; THYMOMA PATIENTS; MYOID CELLS; B-CELLS; MUCOCUTANEOUS CANDIDIASIS; Thymoma; Thymitis; Thymic hyperplasia; Thymic atrophy; Myoid cell; AIRE |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Jun 2020 10:34 |
| Last Modified: | 16 Jun 2020 10:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16434 |
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