Meister, Gunter (2013) Argonaute proteins: functional insights and emerging roles. NATURE REVIEWS GENETICS, 14 (7). pp. 447-459. ISSN 1471-0056, 1471-0064
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Small-RNA-guided gene regulation has emerged as one of the fundamental principles in cell function, and the major protein players in this process are members of the Argonaute protein family. Argonaute proteins are highly specialized binding modules that accommodate the small RNA component - such as microRNAs (miRNAs), short interfering RNAs (siRNAs) or PIWI-associated RNAs (piRNAs) - and coordinate downstream gene-silencing events by interacting with other protein factors. Recent work has made progress in our understanding of classical Argonaute-mediated gene-silencing principles, such as the effects on mRNA translation and decay, but has also implicated Argonaute proteins in several other cellular processes, such as transcriptional regulation and splicing.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIRECTED DNA METHYLATION; PRIMARY PIRNA BIOGENESIS; RNAI ENZYME COMPLEX; DOUBLE-STRANDED-RNA; MESSENGER-RNA; HUMAN-CELLS; CAENORHABDITIS-ELEGANS; C.-ELEGANS; MICRORNA BIOGENESIS; PASSENGER-STRAND; |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Jun 2020 09:54 |
| Last Modified: | 16 Jun 2020 09:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16457 |
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