Riemenschneider, Markus J. and Louis, David N. and Weller, Michael and Hau, Peter (2013) Refined brain tumor diagnostics and stratified therapies: the requirement for a multidisciplinary approach. ACTA NEUROPATHOLOGICA, 126 (1). pp. 21-37. ISSN 0001-6322, 1432-0533
Full text not available from this repository. (Request a copy)Abstract
Individualized therapies are popular current concepts in oncology and first steps towards stratified medicine have now been taken in neurooncology through implementation of stratified therapeutic approaches. Knowledge about the molecular basis of brain tumors has expanded greatly in recent years and a few molecular alterations are studied routinely because of their clinical relevance. However, no single targeted agent has yet been fully approved for the treatment of glial brain tumors. In this review, we argue that multidisciplinary and integrated approaches are essential for translational research and the development of new treatments for patients with malignant gliomas, and we present a conceptual framework in which to place the components of such an interdisciplinary approach. We believe that this ambitious goal can be best realized through strong cooperation of brain tumor centers with local hospitals and physicians; such an approach enables close dialogue between expert subspecialty clinicians and local therapists to consider all aspects of this increasingly complex set of diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHASE-II TRIAL; ENZASTAURIN PLUS TEMOZOLOMIDE; INTEGRATED GENOMIC ANALYSIS; TYROSINE KINASE INHIBITOR; ASPARTIC ACID PEPTIDE; CANCER STEM-CELL; GLIOBLASTOMA-MULTIFORME; RADIATION-THERAPY; MALIGNANT GLIOMAS; OLIGODENDROGLIAL TUMORS; Glioblastoma; Anaplastic glioma; Molecular diagnostics; BRAF; IDH1; MGMT; 1p/19q; Neuropathology; Neurooncology; Chemotherapy; Basic research; Translational research; Clinical research; Tissue banking |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Abteilung für Neuropathologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Jun 2020 09:52 |
| Last Modified: | 16 Jun 2020 09:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16462 |
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