Voeller, Daniel and Ott, Corinna and Bosserhoff, Anja (2013) MicroRNAs in malignant melanoma. CLINICAL BIOCHEMISTRY, 46 (10-11). pp. 909-917. ISSN 0009-9120
Full text not available from this repository. (Request a copy)Abstract
Melanoma is the most aggressive form of skin cancer, and the incidence of melanoma has been increasing faster than that of most other cancers. While the survival rate following surgical resection of early-stage primary tumors is nearly 100%, the survival of patients with metastasized tumors is strongly reduced, likely due to resistance to conventional therapies. Therefore, it is important to use new molecular approaches to develop new biomarkers to better prevent and diagnose melanoma. MicroRNAs (miRNAs) are short non-coding RNAs that post-transcriptionally regulate gene expression via repression of translation or direct degradation of their complementary mRNA. In this review, we summarize our current understanding of the involvement of miRNAs and their corresponding targets in melanomagenesis as well as the potential use of miRNAs as biomarkers. (c) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL-PROLIFERATION; TRANSCRIPTION FACTOR; CUTANEOUS MELANOMA; THERAPEUTIC TARGET; TUMOR PROGRESSION; GENE-EXPRESSION; DOWN-REGULATION; CANCER-CELLS; BODY-FLUIDS; E-CADHERIN; Melanoma; MiRNAs; Diagnostic; Therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Jun 2020 09:43 |
| Last Modified: | 16 Jun 2020 09:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16468 |
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