Ofenloch, Robert F. and Oosterhaven, Jart A. F. and Susitaival, Paivikki and Svensson, Ake and Weisshaar, Elke and Minamoto, Keiko and Onder, Meltem and Schuttelaar, Marie Louise A. and Baskan, Emel Bulbul and Diepgen, Thomas L. and Apfelbacher, Christian (2017) Cross-Cultural Validation of the Quality of Life in Hand Eczema Questionnaire (QOLHEQ). JOURNAL OF INVESTIGATIVE DERMATOLOGY, 137 (7). pp. 1454-1460. ISSN 0022-202X, 1523-1747
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The Quality of Life in Hand Eczema Questionnaire (QOLHEQ) is the only instrument assessing disease-specific health-related quality of life in patients with hand eczema. It is available in eight language versions. In this study we assessed if the items of different language versions of the QOLHEQ yield comparable values across countries. An international multicenter study was conducted with participating centers in Finland, Germany, Japan, The Netherlands, Sweden, and Turkey. Methods of item response theory were applied to each subscale to assess differential item functioning for items among countries. Overall, 662 hand eczema patients were recruited into the study. Single items were removed or split according to the item response theory model by country to resolve differential item functioning. After this adjustment, none of the four subscales of the QOLHEQ showed significant misfit to the item response theory model (P < 0.01), and a Person Separation Index of greater than 0.7 showed good internal consistency for each subscale. By adapting the scoring of the QOLHEQ using the methods of item response theory, it was possible to obtain QOLHEQ values that are comparable across countries. Cross-cultural variations in the interpretation of single items were resolved. The QOLHEQ is now ready to be used in international studies assessing the health-related quality of life impact of hand eczema.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SEVERITY INDEX; GERMAN VERSION; RASCH MODEL; RESPONSIVENESS; RELIABILITY; INSTRUMENTS; POPULATION; DERMATITIS; PSORIASIS; VALIDITY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin Medicine > Institut für Epidemiologie und Präventivmedizin > Medical Sociology |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 19 Feb 2019 12:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1647 |
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